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NNC 05-2090 hydrochloride
CAS No. 184845-18-9
NNC 05-2090 hydrochloride ( NNC05-2090 )
产品货号. M12856 CAS No. 184845-18-9
NNC 05-2090 是一种有效的 mGAT2 选择性 GABA 转运蛋白抑制剂，Ki 为 1.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1725 | 有现货 |
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| 10MG | ￥2568 | 有现货 |
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| 25MG | ￥4334 | 有现货 |
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| 50MG | ￥6253 | 有现货 |
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| 100MG | ￥8748 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NNC 05-2090 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NNC 05-2090 是一种有效的 mGAT2 选择性 GABA 转运蛋白抑制剂，Ki 为 1.4 uM。
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产品描述NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM; displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively; inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM; significantly reduces generalized seizure severity and afterdischarge duration in rats.
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体外实验——
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体内实验Animal Model:Partial sciatic nerve ligation (PSL) mice with mechanical allodynia Dosage:0.01, 0.1 and 0.3 mg/kg Administration:Intraperitoneal injection or intrathecal injection; 0.1 mg/kg, once Result:Dose-dependently reversed mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.
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同义词NNC05-2090
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通路Membrane Transporter/Ion Channel
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靶点GAT
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受体GAT
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研究领域——
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适应症——
化学信息
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CAS Number184845-18-9
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分子量451.01
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分子式C27H31ClN2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (221.73 mM)
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SMILESCOC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl
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化学全称1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5.
2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61.
3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.
